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GMP produced Gallium 68 generator
GMST supplies iThemba GMP produced Gallium 68 generator. With GMP labeled products customers know that all critical processes are clearly defined and validated to ensure that all Gallium 68 generators are in compliance with specifications.

Manufacture of parent radionuclide (⁶⁸Ge)
Accelerator , ⁶⁹Ga(p,2n)⁶⁸Ge

Column material /packing
Modified tin dioxide in a polyethylene column with polyethylene tubing with no metal parts

Eluting Medium
0.6M HCl (suprapure)

⁶⁸Ga yield in 5 ml of eluate
not less than 80%

⁶⁸Ge breakthrough
<0.01%

⁶⁸Ge/⁶⁸Ga generators are produced in quantities of:
10 mCi, 20 mCi, 30 mCi, 40 mCi or 50 mCi
[other quantities on request]

Dimensions of generator
Dimensions: diameter 127 mm and height 180 mm
Weight: 26 kg

Fractionated Elution Procedure
Upon receiving the generator, connect the in-line (clearly marked) of the generator to your 5 ml syringe and flush the system with 0.6 M HCl suprapure solution (5-10 ml).
After 4-5 hours, determination of void volume:
Elute the column collecting 0.5ml fractions and measure each fraction for ⁶⁸Ga.

The fraction's with the highest ⁶⁸Ga specific activity is generally used for labelling purposes.
After elution's, wash the system with 5 ml suprapure 0.6M HCl. Ensure that both the “in” and “out” lines are filled.
It is highly recommended to elute the generator daily to maintain column integrity over the shelf-life of the generator of 9 months.

Radiation levels of ⁶⁸Ga generator
An in-house 50 mCi ⁶⁸Ge/⁶⁸Ga generator was measured.
The measurements directly against the lead shielding surface of the generator are as follows:
The top of the generator ~25 microSeivert/hr (μSv/h)
The sides of the round generator ~100 microSeivert/hour (μSv/h)
At 1m the measurements are close to background reading (~10 μSv/h)
The generator should fit in the existing lead shielding apparatus used in Labs (as per Russian generator size).